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个人简介
教授,博士生导师,营养与食品卫生学系主任。主持国家自然科学基金面上项目5项、浙江省自然科学基金项目、浙江省教育厅项目以及宁波市自然科学基金多项,获省政府科技进步三等奖1项和省科学技术奖一等奖1项。发表论文40余篇,SCI收录论文近30篇。浙江省151人才,宁波市领军和拔尖人才第二层次,浙江省高等学校中青年学科带头人。浙江省教指委委员,健康浙江行动专家咨询委员,区政协委员。
学习和工作经历
1990.09-1995.06 | 获哈尔滨医科大学预防医学 学士学位 |
1995.09-1998.06 | 获哈尔滨医科大学环境卫生学 硕士学位 |
2002.09-2005.06 | 获哈尔滨医科大学营养与食品卫生学 博士学位 |
2007.07-2011.04 | 浙江大学食品科学与工程专业博士后 |
2005-至今 | 宁波大学医学院 |
近年发表的主要论文
1. Intestinal mucus components and secretion mechanisms: what we do and do not know.Exp Mol Med,2023
2. Analysis of fatty acid composition and sensitivity to dietary n-3 PUFA intervention of mouse n-3 PUFA-enriched tissues/organs. Prostaglandins Leukot Essent Fatty Acids,2023
3. Methionine-restricted diet: a feasible strategy against chronic or aging-related diseases. J Agric Food Chem,2023
4. Associations between air pollutant and pneumonia and asthma requiring hospitalization among children aged under 5 years in Ningbo,2015-2017. Front Public Health,2023
5. EPA and DHA differentially coordinate the crosstalk between host and gut microbiota and block the DSS-induced colitis in mice by reinforced colonic mucus barrier. Food & Funct,2022
6. Effects of fructose from apple and honey on serum uric acid in young Chinese: Randomized crossover trials. Asia Pac J Clin Nutr,2022
7. Preparation of concentration dependent nitrogen sulfur Co-doped graphenequantum dots by UV irradiation and reversible optical switch of hydroxypropyl methyl cellulose. Dyes and Pigments,2022
8. The protective effect of sulforaphane on dextran sulfate sodium-induced colitis depends on gut microbial and Nrf2-related mechanism. Frontiers in Nutrition,2022
9. Slimy partners: the mucus barrier and gut microbiome in ulcerative colitis. Exp Mol Med,2021
10. PPAR gamma: The Central Mucus Barrier Coordinator in Ulcerative Colitis. Inflamm Bowel Dis,2021
11. Assessment of causal factors for Parkinson's disease in European populations: A phenome-wide Mendelian randomisation analysis.Asia Pac J Clin Nutr,2021,30(2): 329-339
12. Enhanced antimicrobial activity and pH-responsive sustained release of chitosan/poly (vinyl alcohol)/graphene oxide nanofibrous membrane loading with allicin. Int J Biol Macromol,2020
13. Genome-wide identification of the essential protein-coding genes and long non-coding RNAs for human pan-cancer. Bioinformatics, 2019
14. Endogenous n-3 polyunsaturated fatty acids prevent azoxymethane-induced colon tumorigenesis in mice fed a high-fat diet. Journal of Functional Foods,2018
15. Sulforaphanei improves abnormal lipid metabolism via both ERS-dependent XBP1/ACC &SCD1 and ERS-independent SREBP/FAS pathways. Mol Nutr Food Res,2018
16. Sulforaphane ameliorates glucose intolerance in obese mice via upregulation of insulin signaling pathway. Food & Function,2018
17. Microbiota: a mediator to transform glucosinolate precursors in cruciferous vegetables to the active isothiocyanates.J Sci Food Agric,2018
18. Genome-wide identification of the essential protein-coding genes and long non-coding RNAs for human pan-cancer. Bioinformatics,2019
19. Sulforaphane Improves Abnormal Lipid Metabolism via Both ERS-Dependent XBP1/ACC &SCD1 and ERS-Independent SREBP/FAS Pathways. Mol Nutr Food Res,2018
20. Regulatory network analysis of high expressed long non-coding RNA LINC00941 in gastric cancer. Gene,2018
21. Sulforaphane induces adipocyte browning and promotes glucose and lipid utilization. Mol Nutr Food Res,2016
22. DHA induces mitochondria-mediated 3T3-L1 adicopytes apoptosis by down-regulation of Akt and ERK. Journal of Functional Foods,2015
23. Sulforaphane induces apoptosis in adipocytes via Akt/p70s6k1/Bad inhibition and ERK activation. BBRC,2015
24. Molecular pathways regulating the formation of brown-like adipocytes in white adipose tissue. Diabetes Metab Res Rev,2015
近年主持/参与的项目
1. 基于上皮氧化代谢-菌群-黏液探究EPA改善老化相关的黏液屏障损伤拮抗溃疡性结肠炎作用及机制(82273621),国家自然科学基金面上项目,2023.01~2026.12
2. EPA、DHA调节杯状细胞黏液分泌影响溃疡性结肠炎发生作用及机制研究(81872620),国家自然科学基金面上项目,2019.01~2022.12
3. DHA、EPA抑制炎症、拮抗肥胖相关性肠癌作用的比较研究(81673163),国家自然科学基金面上项目,2017.01~2020.12
4. 诱导白色脂肪细胞褐变和调控脂肪组织代谢在莱菔硫烷抗肥胖中的作用及其分子机制研究(81172660),国家自然科学基金面上项目,2011.01~2015.12
5. 杨梅素诱导脂肪细胞凋亡和重塑细胞表型作用及分子机制研究(30972466),国家自然科学基金面上项目,2010.01~2012.12
6. EPA靶向PPARγ调控结肠上皮细胞氧化代谢抑制溃疡性结肠炎作用研究(LY21H260001),浙江省自然科学基金项目,2021.1~2022.12
7. 莱菔硫烷诱导 3T3-L1脂肪细胞凋亡及MAPK/ERK、PI3k/Akt 通路作用研究(LY14H260001),浙江省自然科学基金项目,2014.01~2016.12
8. 孕期n-3多不饱和脂肪酸营养对子代代谢模式及肥胖的影响研究(Y206583),浙江省自然科学基金项目,2007.1~2009.12
已获授权的发明专利
无
著作编写
1.《预防医学》第四版,东南大学出版社,2021年6月出版(主编)
2.《营养与食品卫生学学习指导与习题集(第三版)》人民卫生出版社,2018年3月出版(副主编)--《营养与食品卫生学》(第8版)配套教材
3.《食品毒理学》科学出版社,2013年7月出版(副主编)
4.《Preventive Medicine, Medical statistics and Epidemiology》,浙江大学出版社,2014年5月出版(参编)
5.《预防医学》第三版,科学出版社,2014年3月出版(参编)
6. 《Preventive Medicine》浙江大学出版社, 978-7-308-81645-1, 2020-08出版,参编
7. 《Preventive Medicine, Medical statistics and Epidemiology》,浙江大学出版社,2014年5月出版(参编)
8. 《预防医学》第三版,参编,东南大学出版社,2014年3月出版
9.《营养与食品卫生学(案例版)》第二版, 科学出版社, 2017年1月出版(参编)
10.《营养与食品卫生学(案例版)》第一版, 科学出版社, 2008年出版(参编)
11.《分子营养学》,人民卫生出版社,2006年出版(参编)
12.《营养与健康》,化学工业出版社 2004年出版(参编)
学术兼职
中国营养学会膳食与烹饪营养分会常务委员
中国营养学会营养与保健食品分会委员
浙江省营养学会理事
宁波市营养学会副理事长
中俄医科大学联盟学术委员会青年委员会理事
浙江省高校中青年学科带头人
宁波市领军和拔尖人才培养工程第二层次
浙江省151人才工程第三层次
健康浙江行动专家咨询委员会专家