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主要从事神经精神疾病包括阿尔茨海默症和精神分裂症认知障碍的神经电生理机制和特异性靶点调控研究。作为项目负责人主持国家级项目1项，省部级项目3项、市级项目4项，横向课题1项和教研项目2项。主持和参与医学专业课程建设项目各2项。发表Nature Communications、Cell Reports、Stem cell reports等高水平研究论文30余篇，其中第一作者或共同第一作者或通讯作者16篇。培养研究生获得2022年宁波大学“卓越”研究生科研成果奖，指导本科生获得生命科学竞赛国家奖，国家级创新研究项目、浙江省新苗项目等。

2.Qing Shang, Yibei Dong, Le Xu, Jianhong Yang, Jiawen Li, Weiyi Yu, Jie Sun, Xiang Gao, Yi Huang, Xiaoqin Zhang*. Environmental Enrichment Improves the Recognition Memory in Adult Mice Following Social Isolation via Downregulation of Kv4.2 Potassium Channels. Molecular Neurobiology. 2023.

3.Xinyi Zhu, Jia Luo, Xiaojie Wei, Luhui Pan, Xiaofan Xu, Linbo Hu, Yibei Dong, Yingke Jiang, Yibei Dong, Le Xu, Limin Xu, Aiming Liu*, Xiaoqin Zhang*. PPARα is involved in high-fat diet-induced risk avoidance impairment via the regulation of hippocampal BDNF. Food & Function. 2023, 14(14):6541-6553.

4.Yingke Jiang, Feiyuan Dong, Yibei Dong, Xinyi Zhu, Luhui Pan, Linbo Hu, Le Xu, Xiaofan Xu, Limin Xu*, Xiaoqin Zhang*. Lateral septal nucleus, dorsal part, and dentate gyrus are necessary for spatial and object recognition memory, respectively, in mice. Frontiers in Behavioral Neuroscience. 2023, 17:1139737.

5.Jing Wang, Yufei Mei, Xiaoqin Zhang#, Xiaojie Wei, Yiping Zhang, Dongpi Wang, Jingjing Huang, Keqing Zhu, Guoping Peng, Binggui Sun*. Aberrant serotonergic signaling contributes to the hyperexcitability of CA1 pyramidal neurons in a mouse model of Alzheimer's disease. Cell Reports. 2023, 42(3):112152.

6.Shuo Li#, Xiao-Qin Zhang#, Chuan-Chuan Liu#, Zhi-Yuan Wang, Guan-Yi Lu, Hao-Wei Shen, Ning Wu, Jin Li*, Fei Li*. IRAS/Nischarin modulates morphine reward by glutamate receptor activation in the nucleus accumbens of mouse brain. Biomedicine & Pharmacotherapy. 2022, 153:113346.

7.Xiaoqin Zhang#, Xiaojie Wei#, Yufei Mei, Dongpi Wang, Jing Wang, Yiping Zhang, Enlu Yang, Xuekun Li, Yan Gu, Guoping Peng, Binggui Sun*. Modulating adult neurogenesis affects synaptic plasticity and cognitive functions in mouse models of Alzheimer's disease. Stem cell reports. 2021, 16(12):3005-3019.

8.Xiaoqin Zhang#, Yufei Mei#, Yang He#, Dongpi Wang, Jing Wang, Xiaojie Wei, Enlu Yang, Dongming Zhou, Haowei Shen, Guoping Peng, Qiang Shu, Xuekun Li, Benyan Luo, Yudong Zhou*, Binggui Sun*. Ablating adult neural stem cells improves synaptic and cognitive functions in Alzheimer models. Stem cell reports. 2021,16(1):89-105.

9.Le Xu#, Yiying Zhou, Linbo Hu, Hongde Jiang, Yibei Dong, Haowei Shen, Zhongze Lou, Siyu Yang, Yunxin Ji, Liemin Ruan*, Xiaoqin Zhang*. Deficits in N-Methyl-D-Aspartate receptor function and synaptic plasticity in hippocampal CA1 in APP/PS1 mouse model of Alzheimer's disease. Frontiers in Aging Neuroscience. 2021, 13:772980.

10.Xiaoqin Zhang #*, Le Xu#, Siyu Yang, Linbo Hu, Feiyuan Dong, Binggui Sun, Haowei Shen*. Reduced synaptic transmission and intrinsic excitability of a subtype of pyramidal neurons in the medial prefrontal cortex in a mouse model of Alzheimer's disease. Journal of Alzheimers Disease. 2021;84(1):129-140.

11.Xiaoqin Zhang, Le Xu, Yu Ling, Linbo Hu, Jing Huang, Haowei Shen*. Diminished excitatory synaptic transmission correlates with impaired spatial working memory in neurodevelopmental rodent models of schizophrenia. Pharmacology Biochemistry and Behavior. 2021, 173103.

12.Xiaoqin Zhang, Hejia Jiang, Le Xu, Siyu Yang, Gaozhe Wang, Hongde Jiang, Teng Wu, Han Du, Zhipeng Yu, Qiqi Zhao, Yu Ling, Zhongyu Zhang, Haowei Shen*. The metabotropic glutamate receptor 2/3 antagonist LY341495 improves working memory in adult mice following juvenile social isolation. Neuropharmacology. 2020, 177:108231.

13.Hejia Jiang, Teng Wu, Siyu Yang, Xiaoqin Zhang*. The roles and mechanisms of parvalbumin positive interneurons underlying the cognitive dysfunction in Alzheimer’s disease and schizophrenia. Progress in Biochemistry and Biophysics. 2020, 47(5):418~425.

14.Xiaoqin Zhang, Zhipeng Yu, Yu Ling, Qiqi Zhao, Zhongyu Zhang, Zhengchun Wang, Haowei Shen*. Enduring effects of juvenile social isolation on physiological properties of medium spiny neurons in nucleus accumbens. Psychopharmacology. 2019, 236(11):3281-3289.

1.国家自然科学基金青年项目，82201322，HCN2通道功能受损在AD伴发癫痫模型认知损伤中的机制研究，2023/01-2025/12，30万元，在研，主持

2.浙江省自然科学基金面上项目，Y24H090019，前扣带回皮层锥体神经元SK通道调控精神分裂症认知功能的机制研究，2024/01-2026/12，10万元，在研，主持

3.宁波市重点研发计划暨“揭榜挂帅”项目子课题，基于奖赏机制的青少年非自杀性自伤风险预警与诊疗技术研究，2023-01-01至2025-12-31，30万元，在研，主持

4.宁波市青年博士创新研究项目，20221JCGY010605，前扣带皮层微环路在 D型丝氨酸改善精神分裂症认知障碍中的机制研究，2022/09-2025/08，20万元，在研，主持

5.浙江省自然科学基金青年项目，LQ20C090002，前额叶皮层兴奋/抑制平衡的α7-nAChR 调控机制在精神分裂症神经发育模型认知功能损伤中的作用，2020/01-2022/12，9万元，结题，主持

6.国家重点实验室开放基金，SKLFNS-KF-201902，食物功能因子岩藻黄素改善阿尔茨海默症认知障碍的突触机制研究，2019/11-2020/11，5万元，结题，主持

7.宁波市自然科学基金，2019A610278，内侧前额叶皮层PV阳性中间神经元在青春期社交隔离小鼠模型工作记忆损伤中的机制研究，2019/1/1-2021/12/30，5万元，结题，主持

8.宁波市自然科学基金，2018A610289，精神分裂症发育障碍模型认知功能损伤的前额叶皮质机制，2018/1/1-2020/10/30，3万元，结题，主持