博彩导航

个人简介

王宁，1986年7月出生，博士，新药技术研究院助理研究员。2012年7月毕业于沈阳药科大学获药理学硕士学位，2018年7月毕业于清华大学获化学博士学位（药物分析方向），导师刘红霞教授。目前发表论文30余篇，授权专利1项，参与编写中西药类书籍3部。主要从事抗癌小分子先导化合物的抗肿瘤活性筛选以及通过代谢组学和蛋白质组学技术探索小分子药物的抗癌作用机理。通过课题的开展，最终找到了多个具有潜力进行后续开发的小分子抗癌先导化合物。

学习和工作经历

2005.09 - 2009.07   沈阳药科大学 中药学士

2009.09 - 2012.07   沈阳药科大学 药理学硕士      

2012.08 - 2013.08   康龙化成（北京）新药技术有限公司  药理部 研究员

2014.09 - 2018.07   清华大学  化学博士

2018.12 - 至今    宁波大学  新药技术研究院 助理研究员

近年发表的主要论文

1. H. Yang, Q.T. Zhang, B. Zhang, Y.F. Zhao*, N. Wang*, Potential Active Marine Peptides as Anti-Aging Drugs or Drug Candidates. Marine Drugs. 2023; 21(3):144.

2. Z. Wang, L. Zhao, B. Zhang, J. Feng, Y. Wang, B. Zhang*, H. Jin, L. Ding, N. Wang*, S. He*, Discovery of novel polysubstituted N-alkyl acridone analogues as histone deacetylase isoform-selective inhibitors for cancer therapy, Journal of Enzyme Inhibition and Medicinal Chemistry 38(1) (2023) 2206581.

3. Z. Hou, Y. Lu*, B. Zhang, A.F.M. Motiur Rahman, Y. Zhao, N. Xi, N. Wang*, J. Wang*, Investigation of the Relationship between Electronic Structures and Bioactivities of Polypyridyl Ru(II) Complexes, Molecules, 28(13) (2023) 5035.

4. C. Guo, X. Liu, F. Xie, H. Ding, S. He, N. Wang*, W. Zhang*, Oricola nitratireducens sp. nov., a novel nitrate reducing bacterium isolated from marine sediment in East China Sea, Antonie van Leeuwenhoek 116(7) (2023) 711-719.

5. Z. Liu, A. Jiang, Y. Wang, P. Xu, Q. Zhang, Y. Wang, S. He, N. Wang*, H. Jin*, B. Zhang*, In silico, synthesis and anticancer evaluation of benzamide tryptamine derivatives as novel eEF2K inhibitors, Bioorganic & Medicinal Chemistry Letters 67 (2022) 128759.

6. C. Yang, S. Zhu, C. Sun, L. Ding, D. Jung, S. He, N. Wang*, W. Zhang*, Pelagibius marinus sp. nov., a novel bacterium isolated from marine sediment, and emended description of the genus Pelagibius, International Journal of Systematic and Evolutionary Microbiology, 72(4) (2022).

7. Y. Lu*, B. Zhang*, N. Wang, M. Li, N. Xi*, Investigation of Major Flavonoids from Artemisia argyi as a Potential COVID-19 Drug: Molecular Docking and DFT Calculations, Crystals, 12(7) (2022) 990.

8. B. Huang*, L. Xu, N. Wang, J. Ying, Y. Zhao, S. Huang*, trans-4-Fluoro-l-proline: A Sensitive 19F NMR Probe for the Rapid Simultaneous Enantiomeric Analysis of Multicomponent Amines, Analytical Chemistry 94(3) (2022) 1867-1873.

9. T. Li, C. Xi, Y. Yu, N. Wang, X. Wang, A. Iwasaki, F. Fang, L. Ding, S. Li, W. Zhang, Y. Yuan, T. Wang, X. Yan, S. He, Z. Cao, C.B. Naman*, Targeted Discovery of Amantamide B, an Ion Channel Modulating Nonapeptide from a South China Sea Oscillatoria Cyanobacterium, Journal of natural products 85(3) (2022) 493-500.

10. Y. Lu*, Z. Hou, M. Li, N. Wang, J. Wang, F. Ni, Y. Zhao, B. Zhang*, N. Xi*, Increasing the cytotoxicity of Ru(ii) polypyridyl complexes by tuning the electron-donating ability of 1,10-phenanthroline ligands, Dalton Transactions 51(42) (2022) 16224-16235.

11. L. Fang, S. He, P. Yin, N. Wang, B. Zhang*, H. Jin*, Design, synthesis, and structure – Activity relationship studies of novel tryptamine derivatives as 5‑HT1B receptor agonists, Journal of Molecular Structure 1265 (2022) 133320.

12. B. Huang*, L. Xu, Z. Zhao, N. Wang, Y. Zhao, S. Huang*, Simultaneous analysis of amino acids based on discriminative (19)F NMR spectroscopy, Bioorganic chemistry 124 (2022) 105818.

13. J. Ying, R. Ding, Y. Zhang, B. Han, Y. Guo, N. Wang, D. Guo, Y. Wu, J. Huang, Y. Liu, F. Ni, S. Huang*, Y. Zhao*, Trimetaphosphate-induced chiral selection between amino acid and nucleoside using 15N-31P coupling NMR, Chinese Chem Lett 33(2) (2022) 821-824.

14. J.-Y. Shi, C.-F. Wang, M.-M. Xie, Y.-J. Hao, N. Wang, H.-B. Ma*, X.-W. Yang*, Brefeldin A from the Deep-Sea-Derived Fungus Fusarium sp. Targets on RIPK3 to Inhibit TNFα-Induced Necroptosis, 19(10) (2022) e202200696.

15. X. Wang, H. Qiu, N. Yang, H. Xie, W. Liang, J. Lin, H. Zhu, Y. Zhou, N. Wang, X. Tan, J. Zhou, W. Cui, D. Teng, J. Wang*, H. Liang*, Fascaplysin derivatives binding to DNA via unique cationic five-ring coplanar backbone showed potent antimicrobial/antibiofilm activity against MRSA in vitro and in vivo, European Journal of Medicinal Chemistry 230 (2022) 114099.

16. Q.T. Zhang, Z. Wang, X. Chen, H. Qiu, Y. Gu, N. Wang*, T. Wang, Z. Wang, H. Ma, Y. Zhao*, B. Zhang*, 8a, a new acridine anticancer lead compound targeting HDAC1/DNMT1. International Journal of Molecular Sciences, 2021, 22, (11), 5516.

17. X. Tan, H. Xie, B. Zhang, J. Zhou, Z.D. Dou, X. Wang*, N. Wang*, A Novel Ivermectin-Derived Compound D4 and Its Antimicrobial/Biofilm Properties against MRSA. Antibiotics, 2021, 10, 208.

18. Q.T. Zhang, Z.D. Liu, Z. Wang, T. Wang, N. Wang, N. Wang*, B. Zhang*, Y.F. Zhao, Recent Advances in Small Peptides of Marine Origin in Cancer Therapy. Marine Drugs, 2021, 19, 115.

19. B. Zhang, J.M. Zou, Q.T. Zhang, Z. Wang, N. Wang*, S. He, Y.F. Zhao, C. B. Naman*, Progress in the Development of Eukaryotic Elongation Factor 2 Kinase (eEF2K) Natural Product and Synthetic Small Molecule Inhibitors for Cancer Chemotherapy. International Journal of Molecular Sciences, 2021, 22, 2408.

20. T. Wang, Q.T. Zhang, N. Wang*, Z.Q. Liu, B. Zhang*, Y.F. Zhao, Research Progresses of Targeted Therapy and Immunotherapy for Hepatocellular Carcinoma, Current Medicinal Chemistry 28(16) (2021) 3107-3146.

21. B. Zhang, T. Zhang, T.Y. Zhang, N. Wang*, S. He, B. Wu, H.X. Jin*, A Novel Methoxybenzyl 5-Nitroacridone Derivative Effectively Triggers G1 Cell Cycle Arrest in Chronic Myelogenous Leukemia K562 Cells by Inhibiting CDK4/6-Mediated Phosphorylation of Rb. International Journal of Molecular Sciences, 2020, 21, 5077.

22. B. Zhang, Q.T. Zhang, Z.D. Liu, N. Wang*, H.X. Jin, F. Liu, C.L. Zhang, S. He*, Synthesis and Anticancer Research of N‐(2‐aminophenyl)benzamide Acridine Derivatives as Dual Topoisomerase I and Isoform‐Selective HDAC Inhibitors. ChemistrySelect, 2020, 5, 8311-8318.

23. B. Zhang, Z.D. Dou, Z. Xiong, N. Wang*, S. He, X.J. Yan, H.X. Jin*, Design, synthesis and biological research of novel N-phenyl benzamide-4 methylamine acridine derivatives as potential topoisomerase I/II and apoptosis-inducing agents, Bioorganic & Medicinal Chemistry Letters, 2019, 23, 126714.

24. N. Wang, P.P. Qiu, W.Cui, X.J. Yan, B. Zhang* and S. He*, Recent advances in multi-target anti-Alzheimer disease compounds (2013 up to present), Current Medicinal Chemistry, 2019, 26, 5684-5710.

25. N. Wang¹, B. Zhang¹, F. Jin, D. Gao, F. Liu, H. X. Liu, Y. Y. Jiang, Combing metabolomics with bioanalysis methods to study theantitumor mechanism of the new acridone derivative 8q on CCRF-CEM cells: 8q induced mitochondrial-mediated apoptosis andtargeted the PI3K/AKT/FOXO1 pathway. Journal of Pharmaceutical and Biomedical Analysis, 2018, 160,314-322.

26. N. Wang¹, S. P. Chen¹, B. Zhang, S. F. Li, F. Jin, D. Gao, H. X. Liu, Y. Y. Jiang, 8u, a pro-apoptosis/cell cycle arrest compound, suppresses invasion and metastasis through HSP90α downregulating and PI3K/Akt inactivation in hepatocellular carcinoma cells. Scientific Reports, 2018, 8, 309.

27. B. Zhang¹, N. Wang¹, C.L. Zhang, C.M. Gao, W. Zhang, K. Chen, W.B. Wu, Y.Z. Chen, C.Y. Tan, Y.Y. Jiang, Novel multi-substituted benzyl acridone derivatives as survivin inhibitors for hepatocellular carcinoma treatment. European Journal of Medicinal Chemistry, 2017. 129, 337-348.

近年主持/参与的项目

1. 宁波市公益基金（2022.07-2023.06）- 主持；

2. 国家重点实验室开放基金（2020.01-2020.12）- 主持；

已获授权的发明专利

2021.一种 1，2，3，4-四氢叶啶-9-胺类化合物及其制备方法和用途（CN112409335B）

著作编写

1. 《常用中成药物安全用药手册》，辽宁科学技术出版社，2011.

2. 《常用中药材安全用药手册》，辽宁科学技术出版社，2011.

3. 《常用西药安全用药手册》，辽宁科学技术出版社，2011.

学术兼职

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