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个人简介

2018年12月于吉林大学理论化学研究所获得物理化学博士学位，在读期间主要从事生物大分子的分子动力学模拟，以及生物酶催化反应机理的研究工作。2019年1月入职于宁波大学新药技术研究院，加入王永研究员团队，从事非血红素仿生化学体系的理论研究工作。目前以第一作者及通讯作者在J. Am. Chem. Soc.、Inorg. Chem.、Chem. Comm.、Chin. Chem. Lett.、Dalton Trans.、Front. Chem.等国际著名学术期刊上10篇。主持浙江省自然科学基金1项，国家重点实验室开放课题1项，宁波市自然科学基金一项，参与国家自然科学基金重大研究计划项目1项。

学习和工作经历

2013.09-2018.12 吉林大学 物理化学博士

2019.01- 至今  宁波大学 新药技术研究院 助理研究员

近年发表的主要论文

(1) Dongru Sun, Zhimin Wu, Xuan Zhang, Jindou Yang, Yufen Zhao, Wonwoo Nam,* and Yong Wang*. Brønsted Acids Promote Olefin Oxidations by Bioinspired Nonheme Co^III(PhIO)(OH) Complexes: A Role for Low-Barrier Hydrogen Bonds, J. Am. Chem. Soc., 2023 145, 5739−5749.

(2) Zhimin Wu, Xuan Zhang, Lanping Gao, Dongru Sun*, Yufen Zhao, Wonwoo Nam,*and Yong Wang*. Elusive Active Intermediates and Reaction Mechanisms of ortho-/ipso-Hydroxylation of Benzoic Acid by Hydrogen Peroxide Mediated by Bioinspired Iron(II) Catalysts. Inorg. Chem. 2023, 62, 14261−14278.

(3) Zhimin Wu, Dongru Sun*, Yong-Min Lee, Yufen Zhao, Wonwoo Nam* and Yong Wang*. The elusive active species in nickel(II)-mediated oxidations of hydrocarbons by peracids: a Ni^II–oxyl species, an aroyloxy radical, or a Ni^II–peracid complex? Dalton Trans., 2023, 52, 8676–8684.

(4) Anran Zhou, Xiao-Xi Li, Dongru Sun*, Xuanyu Cao, Zhimin Wu, Huanhuan Chen, Yufen Zhao, Wonwoo Nam* and Yong Wang*. Theoretical investigation on the elusive structure– activity relationship of bioinspired high-valence nickel–halogen complexes in oxidative fluorination reactions, Dalton Trans., 2023, 52: 1977-1988.

(5) Xiaolu Chen , Dongru Sun*, Lanping Gao, Yufen Zhao, S. de visser, and Yong Wang*, Theoretical Studies Unveil the Unusual Bonding in Oxygenation Reactions Involving Cobalt(II)-Iodylarene Complexes, Chem. Commun. 2021, 57, 3115.

(6) Lanping Gao, Xiaolu Chen, Dongru Sun*, Hua Zhao, Yufen Zhao, Wonwoo Nam*, Yong Wang* Theoretical Investigation on the Elusive Biomimetic Iron(III)-Iodosylarene Chemistry in Oxygenation: An Unusual Hydride Transfer Triggers the Ritter Reaction, Chin. Chem. Lett. 2021. 32. 3857-3861.

(7) Dongru Sun,*, Xiaolu Chen, Lanping Gao, Yufen Zhao, and Yong Wang*. Theoretical Study on the Structural-Function Relationship of Manganese(III)-Iodosylarene Adducts, Front. Chem. 2020, 8, 744.

(8) Dongru Sun, Qingchuan Zheng*, Hongxing Zhang. Probing the interaction mechanism of small molecule inhibitors with matriptase based on molecular dynamics simulation and free energy calculations. J. Bio. Struct. Dyn., 2017, 35(4): 755-764.

(9) Dongru Sun, Qingchuan Zheng*, Hongxing Zhang. Molecular dynamics investigation of stereoselective inhibition mechanism of HIF-2α/ARNT heterodimer. J. Mol. Recogin, 2018, 31(1):e2675.

(10) Dongru Sun, Qingchuan Zheng*, Hongxing Zhang. Exploring the inhibition mechanism on HIF-2 and structural advantage of preclinical inhibitor PT2399 by molecular dynamics simulations. J. Mol. Recogin. 2018,e2730.

(11) Anran Zhou, Xuanyu Cao, Huanhuan Chen, Dongru Sun, Yufen Zhao, Wonwoo Nam* and Yong Wang*. The chameleon-like nature of elusive cobalt–oxygen intermediates in C–H bond activation reactions. Dalton Trans., 2022, 51, 4317-4323.

(12) Xianglong Li, Miao Yang, Dongru Sun, Jianping Shi, Ming Yang, Yanbin Feng* and Song Xue. Unique recognition of the microalgal plastidial glycerol-3-phosphate acyltransferase for acyl-ACP. Plant Science, 2003, 332, 111725.

(13) Huanhuan Chen, Anran Zhou, Dongru Sun, Yufen Zhao, and Yong Wang*. Theoretical Investigation on the Elusive Reaction Mechanism of Spirooxindole Formation Mediated by Cytochrome P450s: A Nascent Feasible Charge-Shift C−O Bond Makes a Difference. J. Phys. Chem. B. 2021, 125, 8419-8430.

(14) Hua Zhao, Peng Shen, Dongru Sun, Hongbin Zhai*,Yufen Zhao. The Regioselective Functionalization Reaction of Unprotected Carbazoles with Donor–Acceptor Cyclopropanes. J. Org. Chem. 2021, 86,9189-9199.

(15) Zhiqiang Fu, Lili Yang, Dongru Sun, Zexing Qu, Yufen Zhao, Jiali Gao* and Yong Wang*. Coupled electron and proton transfer in the piperidine drug metabolism pathway by the active species of cytochromes P450. Dalton Trans., 2020, 49,11099-11107.

近年主持/参与的项目

1.分子反应动力学国家重点实验室开放基金（2020-01——2020-12） - 与心血管疾病相关的前列环素合成酶代谢机理和动力学的理论研究 - 主持

2.浙江省自然科学基金（2020-01——2022-12） - 前列环素合成酶PGIS催化机理及动力学的理论研究 - 主持

3.宁波市自然科学基金（2021-12——2023-11） - 与心血管疾病相关的细胞色素P450同工酶催化机理及动力学的理论研究 - 主持

4.国家自然科学基金重大研究计划（2023-01——2026-12-31） - 磷调控核苷对多肽合成的手性选择、传递及放大机制研究 - 参与

已获授权的发明专利

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著作编写

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学术兼职

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