On August 22-24, the 2022 National College Student Life Science Competition was successfully held online. Through an intense competition for nearly a year, the project “Study on the Inactivation of INF2 Ubiquitination Degradation by FBXO7 of Endometrial Cancer Mutation Origin” was awarded the national First Prize.

     Project Name: Study on the Inactivation of INF2 Ubiquitination Degradation by FBXO7 of Endometrial Cancer Mutation Origin

    Team Members: Ni Xiaoqi, Jin Jiabo, Cao Xinyi, Li Xinming, He Jian

     Instructor: Jin Xiaofeng

     Project Overview: Endometrial cancer, as one of the most common malignant tumors in female reproductive system, features a very high recurrence and metastasis rate, and abnormal chondriokinesis plays an important role in the recurrence and metastasis of endometrial cancer. The Project has revealed that INF2, an upstream regulator of mitochondrial division, has an interactive effect with its upstream E3 ubiquitin ligase junction protein FBXO7. Furthermore, high-frequency mutations exist in FBXO7 in endometrial cancer, and FBXO7 mutants are deprived of the ability to interact with INF2 and degrade ubiquitination. On this basis, this study has focused on the interaction between FBXO7 and INF2, the ubiquitination modification and functional regulation of INF2 by FBXO7, as well as the effects of high INF2 expression and FBXO7 mutation in endometrial cancer tissues, and investigated the possibility of INF2 and FBXO7 as biomarkers for recurrence and metastasis of endometrial cancer and targets for precision therapy.